One person was pronounced dead at the scene, and the other died at Huntsville Hospital from injuries, West said.

The eastbound lanes of I-565 were closed as of 5 p.m., and one westbound lane was open, said Seth Burkett, Alabama Department of Transportation spokesman.

Eastbound traffic from I-565 is being detoured to County Line Road.

Traffic is backed up “a significant distance,” Burkett said. He advised motorists to avoid I-565 if possible.

Huntsville Police Department is working the incident, and the fire is still under investigation.